av·e·nue / ˈavəˌn(y)oō/ • n. 1. a broad road in a town or city, typically having trees at regular intervals along its sides. ∎ [in proper names] a thoroughfare running at right angles to the streets in a city laid out on a grid pattern: 7th Avenue. ∎ a tree-lined road or path, esp. one that leads to a country house or similar building: an avenue of limes.2. a way of approaching a problem or making progress toward something: three possible avenues of research suggested themselves.